Subconjunctival bevacizumab for corneal neovascularization
نویسندگان
چکیده
منابع مشابه
Subconjunctival bevacizumab injection for corneal neovascularization in recurrent pterygium.
PURPOSE We report on the use of subconjunctival bevacizumab on corneal vessel density in recurrent pterygia. METHODS The charts of 5 patients with recurrent pterygium, who received subconjunctival injections of bevacizumab (2.5 mg/0.1 ml) were retrospectively reviewed. Ophthalmic evaluation included Snellen visual acuity (VA), tonometry and complete examination before the injection and at 1 w...
متن کاملSubconjunctival injection of bevacizumab (avastin) on corneal neovascularization in different rabbit models of corneal angiogenesis.
PURPOSE Bevacizumab is a potent recombinant humanized monoclonal antibody directed against vascular endothelial growth factor (VEGF). The purpose of this study was to evaluate the therapeutic effect of subconjunctival injection of bevacizumab on corneal neovascularization (NV) in different rabbit models. METHODS Several rabbit models of corneal NV were used, including (1) a corneal micropocke...
متن کاملSubconjunctival bevacizumab, a potential therapeutic strategy for treatment of corneal neovascularization
Purpose: feasibility of local application of bevacizumab for inhibition and treatment of corneal angiogenesis. Materials and Methods: 20 pigmented rabbits with average weight 3.7±0.4 kg were numbered and two groups were made, Group A: the rabbits of this group were subjected to corneal sutures application to induce corneal vascularization. Group B: rabbits of this group were subjected to cornea...
متن کاملComparison of the effects of subconjunctival and topical anti-VEGF therapy (bevacizumab) on experimental corneal neovascularization.
PURPOSE To compare the effects of bevacizumab applied either subconjunctivally or topically, in a rat model of corneal neovascularization induced by alkali burn. METHODS The right corneas of 24 Wistar-Albino rats were cauterized with silver nitrate sticks. The rats were divided randomly and equally into three groups: no treatment control (n=8), subconjunctival bevacizumab treatment (n=8), and...
متن کاملTopical bevacizumab therapy for corneal neovascularization.
Angiogenesis has been defined as the formation of new blood vessels from preexisting vascular structures. Corneal neovascularization (NV) occurs when the balance between angiogenic and antiangiogenic factors shifts toward angiogenic factors. Vascular endothelial growth factor (VEGF) has been found to be a significant angiogenic factor in corneal NV in human and animal models. Therapy specifical...
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ژورنال
عنوان ژورنال: Acta Ophthalmologica
سال: 2010
ISSN: 1755-375X
DOI: 10.1111/j.1755-3768.2009.01585.x